Enhancement of Bilirubin Excretion in Alloxan - Induced Diabetic Rats Treated with Crude Aloe vera Gel

This study was aimed at determining the effect of type 1 diabetes mellitus on bilirubin excretion, and to ascertain the impact of treatment with crude Aloe vera gel on bilirubin excretion. The phyto-constituents and median lethal dose of the plant material were determined before administration. Forty albino wistar rats were randomly assigned into four groups of 10 rats each as follows; control group, alloxan induced diabetic untreated group (DM), alloxan induced diabetic treated group (DMT) and control treated group (CT). The dose of crude Aloe vera gel used for this study was 0.2ml/100g body weight daily, per oral route. Biliary total bilirubin (BTB) and serum total bilirubin (STB) concentrations were significantly (p<0.001) increased in the DM group compared to control, DMT and CT group. BTB and STB concentrations were significantly lower (p<0.001) in DMT group compared to DM group. BTB and STB concentrations were significantly reduced in the CT group compared to control. Biliary conjugated bilirubin (BCB) and serum conjugated bilirubin (SCB) concentrations were significantly lower (p<0.001) in the DM, DMT and CT group compared to control. BCB and SCB concentrations were significantly lower (p<0.001) in the DMT group compared to DM group. BCB and SCB concentrations were significantly lower (p<0.001) in the CT group compared to control. Biliary unconjugated bilirubin (BUB) and serum unconjugated bilirubin (SUB) concentrations were significantly increased (p<0.001) in the DM group compared to control, DMT and CT group. BUB and SUB concentrations were significantly reduced (p<0.001) in CT group compared to control. These results are suggestive of the fact that crude Aloe vera gel enhances excretion of bilirubin in diabetic and normal conditions.